Vitamin B6 occurs in 3 forms–pyridoxine, pyridoxamine, and pyridoxal. B6 is absorbed within the large intestine. The muscle stores more or less 75 80 % of the vitamin although the live stores approximately 5 10 %.
B6 is recommended for transaminations, decarboxylations, dehydratases, side-chain cleavage reactions, and ammonia release. Its aldehyde group acts as a Schiff base to react with the amino groups of amino acids. It basically acts to shuttle nitrogen between compounds.
Functions- The three forms of B6 can all be switched into on the coenzyme PLP which helps in transamination & protein metabolism. PLP is vital for glycogen degradation; it also will help with the development of the neurotransmitter, serotonin, the nonprotein part of hemoglobin (heme), nucleic acids, and lecithin. Vitamin B6 is essential for the metabolic process of tryptophan to niacin.
· Transaminations These reactions are needed to recycle as well as reuse nitrogen in the entire body. They are the first step in amino acid catabolism as well as the very last phase in the synthesis of nonessential amino acids. Example: a-ketoglutarate + asparate glutamate + oxaloacetate
· Serine/ Threonine Deamination (Dehydratases) This response has the production of the a keto acids of serine and also threonine through oxidative removal of N as ammonia Example: Serine a-keto-serine + NH4+
· Decarboxylation These reactions often occur on the neuroactive amines of GABA., histamine, tyramine, and seratonin They also are critical in porphyrin synthesis, intermediates inside the synthesis of sphingomyelin, lecithin and taurine, and for the description and desulfuration of cysteine.
· Glycogen Phosphorylase fifty % of all B6 in the body is certain to glycogen phosphorylase however, the importance is unknown. The reaction is important for recycling of folate and is as follows:
Serine glycine + 5,10-methylene-THF
Deficiency Deficiencies of vitamin B6 are relatively uncommon. People with a diet lacking in vitamin B6 will 1st show signs of weakness, irritability, insomnia, nervousness, and moist skin lesions. Much more advanced symptoms include growth failure, impaired motor function, hypochromic microcytic anemia, smooth tongue, along with convulsions.
The impaired motor performance as well as other mental issues can be traced to a decrease in amino acid-based neurotransmitters (serotonin, GABA, tyramine, epinephrine). You see a growth in urea excretion due to a decrease synthesis of nonessential amino acids. The nitrogen from these amino acids is not reprocessed by transamination and instead is excreted as well as lost. You see a rise in urinary excretion particularly within the succeeding amino acids: metabolites of glycine, methionine, and tryptophan. The hypochromic microcytic anemia is simply because that there’s a decreased synthesis of the B6 dependent porphyrin ring of hemoglobin.
meal service delivery who are at most risk include the older folk with substandard vitamin intake, alcoholics, hemodialysis patients, and those people that are on drug therapy. Overall, individuals with a high metabolic stress.
Sources Foods richest in vitamin B6 include:
o whole grains o legumes o nuts o navy beans o walnuts o meat (sirloin plus chicken) o fish (salmon and shellfish) o bananas as well as apples o broccoli and spinach
Therapeutics Vitamin B6 could provide therapeutic advantages due to the next syndromes: carpal tunnel syndrome, glucose intolerance, sideroblastic anemia, neurologic problems, hyperoxaluria, convulsive seizures, monosodium glutarate (MSG) intolerance, premenstral syndrome (Immune function and pms). Moreover, vitamin B6 might help reduce homocysteine levels and hence the chance of acquiring cardiovascular disease.